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Allocycly of the X-chromosome in tumors and normal tissues.
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1960
Year
SpermatogenesisCytogeneticsGeneticsPathologyReproductive BiologyEpigeneticsReproductive EndocrinologyInterphase NucleiHeteropyknotic ChromosomeMale InfertilityGametogenesisPublic HealthNormal TissuesBittner Milk AgentHistopathologyMeiosisChromosomal RearrangementSex ChromosomesChromatinChromosome DynamicsDevelopmental BiologyChromatin StructureChromosome BiologyMedicineChromosome 9
Summary A single, deeply staining heteropyknotic chromosome, most conspicuous during prophase in neoplastic and normal diploid female cells of mouse and rat, is interpreted as one of the two X-chromosomes. Tetraploid female nuclei often contain two such elements, tetraploid male nuclei only one. Tjio and Ostergren9s (1958) explanation of this phenomenon as a symptom of chromosomal infection with the Bittner milk agent appears untenable. The observed allocycly of the X-chromosome has a bearing on the constitution of the “sex chromatin” in interphase nuclei which is usually composed of the heterochromatin of a single positively heteropyknotic X, rather than two paired X9s.