Genetic control of immune responsiveness to a glutamic acid, alanine, tyrosine copolymer in mice. I. Linkage of responsiveness to H-2 genotype.

Abstract

Mice of various strains were immunized with a random terpolymer of glutamic acid 60 alanine 30 tyrosine 10 (GAT 10 ). The ability to produce significant anti-GAT 10 antibody, detected by an antigen-binding assay, was possessed by mice of H-2 a , H-2 b , H-2 d , H-2 k histocompatibility alleles. Mice with H-2 p and H-2 s alleles were non-responders. Congenic mice that differed only at the H-2 locus responded according to their H-2 type.