Heterotopic urinary bladders in rats produced by an isograft inoculum of bladder fragments and air.

Abstract

A pseudobladder is formed by inoculating rats s.c. with a combination of rat bladder fragments and air. Within 1 month a cyst is produced that is lined completely by normal-appearing urothelium. The heterotopic pseudobladder persists for as long as 6 months. In some 6-month-old bladder walls, foci of bone formation are found in the stroma underlying the urothelium. The lining epithelium at all stages from 1 to 6 months is characteristic of normal urothelium by light and electron microscopic criteria.