Synthesis and Fungicidal Activities of Novel Quinazoline Derivatives Containing 1,2,4-Triazole Schiff-Base Unit

Abstract

Using 3-methyl-4-amino-1,2,4-triazole-5-thione, aromatic aldehydes and 4-chloroquinazoline as starting materials, fourteen novel quinazoline derivatives containing 1,2,4-triazole Schiff-base unit were synthesized. The structures of target compounds were fully characterized by IR, 1 H NMR, MS and elemental analysis. The preliminary bioassay showed that some compounds possessed certain fungicidal activities. At the concentration of 50 g/mL, the inhibition rates of compound 6g against F. oxysporium, C. mandshurica and P. infestans were 71%, 72% and 58%, respectively.