Concepedia

Are altered pharmacokinetics of non‐steroidal anti‐inflammatory drugs (NSAIDs) a risk factor for gastrointestinal bleeding?

Hilary Wynne, Anna Long, E Nicholson, Alan C. Ward, D. Keir

British Journal of Clinical Pharmacology · 1998 · 18 citations · 16 references

DOIFull text

Open access

Abstract

The data failed to support the hypothesis that reduced clearance of NSAIDs, which results in higher plasma concentrations, is a risk factor for acute gastrointestinal haemorrhage.

References

16

Prediction of Creatinine Clearance from Serum Creatinine

Donald W. Cockcroft, Henry Gault · Nephron · 1976 · 15.3K citations

Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

Fred E. Silverstein · Annals of Internal Medicine · 1995 · 1.1K citations

Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

La García Rodríguez, Hershel Jick · The Lancet · 1994 · 976 citations

, , +11

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND BLEEDING PEPTIC ULCER

K W Somerville, Gail Faulkner, M. J. S. Langman · The Lancet · 1986 · 545 citations

, , +6

Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage.

M J Langman, Larissa E. Morgan, A.P. Worrall · BMJ · 1985 · 343 citations · Full text

, , +14