The anti‐protozoal drug pentamidine blocks K<sub>IR</sub>2.x‐mediated inward rectifier current by entering the cytoplasmic pore region of the channel - Concepedia

Concepedia

Publication | Open Access

The anti‐protozoal drug pentamidine blocks K<sub>IR</sub>2.x‐mediated inward rectifier current by entering the cytoplasmic pore region of the channel

DOI Full Paper Access

42

Citations

42

References

2010

Year

Teun P. de Boer, Lukáš Nalos, Anna Stary, Bart Kok, Mjc Houtman, Gudrun Antoons, TAB Van Veen, JDM Beekman, BL De Groot, Tobias Opthof,

British Journal of Pharmacology

Abstract

Pentamidine inhibits cardiac I(K1) by interacting with three negatively charged amino acids in the cytoplasmic pore region. Our findings may provide new insights for development of specific I(K1) blocking compounds.

References

	Year	Citations

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