LABORATORY-ACQUIRED TULAREMIA IN VACCINATED INDIVIDUALS: A REPORT OF 62 CASES

Abstract

Article1 March 1959LABORATORY-ACQUIRED TULAREMIA IN VACCINATED INDIVIDUALS: A REPORT OF 62 CASESTHOMAS E. VAN METRE JR., PAUL J. KADULL, M.D.THOMAS E. VAN METRE JR., PAUL J. KADULL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-3-621 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA high incidence of tularemia among nonvaccinated laboratory workers has been recognized.1-12 Almost every individual who consistently works with Pasteurella tularensis eventually incurs infection; those casually exposed may escape.3, 4The clinical features of laboratory-acquired tularemia in nonvaccinated and previously uninfected individuals have been described in detailed reports of at least 19 cases.4-9 In general, these patients had a typhoidal illness, with moderate to severe symptoms and a relatively high incidence of chronic disability. No ulceroglandular cases have been reported. Several asymptomatic cases have been observed.Tularemia has been reported in laboratory workers presumably immunized by prior infection. Francis2cited...Bibliography1. KadullReamesCoriellFoshay PJHRLLL: Studies of tularemia. V. Immunization of man, J. Immunol. 65: 425-435 (Nov.) 1950. MedlineGoogle Scholar2. Francis E: Immunity in tularemia, Tr. A. Am. Physicians 51: 394-398, 1936. Google Scholar3. FoshayHesselbrookWittenbergRodenberg LWHJJAH: Vaccine prophylaxis against tularemia in man, Am. J. Pub. Health 32: 1131-1145 (Oct.) 1942. CrossrefGoogle Scholar4. Francis E: Tularemia Francis 1921: a new disease of man, Hygienic Laboratory Bulletin No. 130, 1922, Government Printing Office, Washington. Google Scholar5. LedinghamFraser JCFE: Tularemia in man from laboratory infection, Quart. J. Med. 17: 365-382 (July) 1924. CrossrefGoogle Scholar6. ParkerSpencer RRRR: Six additional cases of laboratory infection of tularemia in man, Pub. Health Rep. 41: 1341-1355, 1926. CrossrefMedlineGoogle Scholar7. Dieter LV: A case of tularemia in a laboratory worker, Pub. Health Rep. 41: 1355-1357, 1926. CrossrefGoogle Scholar8. Author unknown: Psittacosis and tularemia: report of cases—infection of 2 laboratory workers in California; recovery, California and West. Med. 44: 79-80, 1936. MedlineGoogle Scholar9. Golem SB: Two inapparent out of four laboratory tularemia infections, Peliklinik, Instanbul 9: 144-148, 1941. Google Scholar10. HoweCoriellBookwalterEllingson CLLHCHV: Streptomycin treatment in tularemia, J. A. M. A. 132: 195-200 (Sept. 28) 1946. CrossrefMedlineGoogle Scholar11. GreenEigelsbach TWHT: Immunity in tularemia. Report of two cases of proved reinfection, Arch. Int. Med. 85: 777-782 (May) 1950. CrossrefGoogle Scholar12. AshburnMiller LLSE: Tularemia. A report of a laboratory infection fatal on the fifth day with early pulmonary involvement; autopsy, Arch. Path. 39: 388-392, 1945. Google Scholar13. DownsCoriellEigelsbachPlettPinchotOwen CMLLHTKFGBBJ: Studies on tularemia. I. Immunization of white rats, J. Immunol. 56: 229-243 (July) 1947. MedlineGoogle Scholar14. Foshay L: Final Report—Contract DA-18-064-CML-2394, The Chemical Corps Biological Laboratories, Camp Detrick, Md., 1 May 1953-30 April 1955. Google Scholar15. JohanssonFerris KRDH: Photography of airborne particles during bacteriologic plating operations, J. Infect. Dis. 78: 238-252, 1956. CrossrefGoogle Scholar16. ReitmanWedum MAG: Microbiologic safety, Pub. Health Rep. 71: 659-665 (July) 1956. CrossrefMedlineGoogle Scholar17. Foshay L: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 22, 1958.From the Biological Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, and Fort Detrick, Frederick, Maryland.Released for general publication by the U. S. Army Chemical Corps.†Supported by a contract between the U. S. Army Chemical Corps, Fort Detrick, Frederick, Maryland, and The Johns Hopkins University.Requests for reprints should be addressed to Thomas E. Van Metre, Jr., M.D., 1014 Saint Paul Street, Baltimore 2, Maryland. 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JOHNSON, M.D., ROBERT J. ELLIS, Ph.D.Laboratory-acquired Q feverAn analysis of forty-two cases of laboratory-acquired tularemiaProtection against Infection in the Microbiological Laboratory: Devices and Procedures 1 March 1959Volume 50, Issue 3Page: 621-632KeywordsAntibioticsClinical laboratoriesDisabilitiesInhalationLesionsResearch laboratoriesRisk managementTularemiaTyphoidUlcers ePublished: 1 December 2008 Issue Published: 1 March 1959 PDF downloadLoading ...