VITAMIN D INTOXICATION: REPORT OF TWO CASES TREATED WITH CORTISONE

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Article1 April 1958VITAMIN D INTOXICATION: REPORT OF TWO CASES TREATED WITH CORTISONEJOHN V. VERNER JR., M.D., FRANK L. ENGEL, M.D., HARRY T. MCPHERSON, M.D.JOHN V. VERNER JR., M.D.Search for more papers by this author, FRANK L. ENGEL, M.D.Search for more papers by this author, HARRY T. MCPHERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-4-765 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExcessive vitamin D ingestion has been known since 1928 to produce toxic effects in humans.1 Knowledge of these harmful effects has in recent years led physicians away from the use of large doses of this vitamin. The syndrome of vitamin D intoxication still occurs, however, and may present difficult diagnostic and therapeutic problems. Donegan et al.2 reported two such cases from this institution in 1949. Two additional cases are reported here because of the gratifying response to cortisone therapy and because they manifest interesting features not sufficiently stressed in the existing literature.CASE REPORTSCase 1. This 71 year old...Bibliography1. HessLewis AFJM: Clinical experience with irradiated ergosterol, J. A. M. A. 91: 783-788, 1928. CrossrefGoogle Scholar2. DoneganMesserOrgain CKALES: Vitamin D intoxication due to estron: report of two cases, Ann. Int. Med. 30: 429-435, 1949. LinkGoogle Scholar3. AnningDawsonDolbyIngram STJDEJT: Toxic effects of calciferol, Quart. J. Med. 17: 203-228, 1948. MedlineGoogle Scholar4. ChaplinClarkRopes HLDMW: Vitamin D intoxication, Am. J. M. Sc. 221: 369-378, 1951. CrossrefMedlineGoogle Scholar5. CoveyWhitlock GWHH: Intoxication resulting from the administration of massive doses of vitamin D, with report of five cases, Ann. Int. Med. 25: 508-515, 1946. LinkGoogle Scholar6. HowardMeyer JERJ: Intoxication with vitamin D, J. Clin. 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Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina*Received for publication July 2, 1957.From the Department of Medicine and Division of Endocrinology, Duke University, Durham, North Carolina.Requests for reprints should be addressed to Frank L. Engel, M.D., Division of Endocrinology, Duke University School of Medicine, Durham, North Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byJohn V. Verner Jr. and Ashton B. 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HUNT, M.B., CH.B., EDMUND REINHOLD YENDT, M.D., F.R.C.P.Electrolyte Complications of Drug TherapyRenal LithiasisThe diagnostic spectrum of hypercalcemiaDie Pathologie der Avitaminosen und HypervitaminosenRenal Tubular Acidosis and Renal Potassium Wasting Acquired as a Result of Hypercalcemic NephropathyBONE CHANGES ASSOCIATED WITH CORTISONE ADMINISTRATION IN THE RAT : CONVERSION OF ‘RICKETS’ TO ‘OSTEOPOROSIS’Sarcoidosis and Hyperparathyroidism with HypercalcemiaTHE SYMPTOMS OF HYPERCALCEMIA ASSOCIATED WITH SARCOIDOSIS MASQUERADING AS PEPTIC ULCER*ANTHONY J. RICHTSMEIER, M.D., F.A.C.P.IDIOPATHIC HYPOPARATHYROIDISM AND IDIOPATHIC ADRENAL CORTICAL INSUFFICIENCY OCCURRING WITH CYSTIC FIBROSIS OF THE PANCREAS*F. GILBERT MCMAHON, M.S., M.D., DAVID U. COOKSON, M.D., J. D. KABLER, M.D., STANLEY L. INHORN, M.D.TREATMENT OF ATYPICAL CASES OF SURGICAL HYPOPARATHYROIDISM 1 April 1958Volume 48, Issue 4Page: 765-773KeywordsCalciumEndocrinologyHypercalcemiaIngestionIntoxicationSaltsVitamin D ePublished: 1 December 2008 Issue Published: 1 April 1958 PDF downloadLoading ...