The Journal of Immunology · 1974 · 34 citations · 0 references
Life SciencesImmunologyAdaptive ImmunityCellular ImmunologyHypersensitivityCell-mediated ImmunityDelayed-type HypersensitivityEffector T Cell FunctionHelper T Cell SubsetsT Cell BiologyT Cell ToleranceDelayed Hypersensitivity ReactionsHapten-protein ConjugatesHelper T Cell Effector FunctionProtein Carrier SystemsT Cell Effector FunctionsT Helper Cell Effector FunctionsT Helper CellsT-cell Mediated Responses
Abstract The effect of tolerization with varying doses of deaggregated protein carrier on two T cell functions—delayed hypersensitivity (DHS) to the carrier and helper functions for the secondary anti-hapten antibody response to a hapten carrier conjugate—was studied. It was found that high doses of tolerogen inhibit the development of both DHS and helper function, while low doses of tolerogen inhibit the development of helper function but not of DHS.