Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection

Abstract

GBP5 is known to play a role in inflammasome assembly during immune response. However, the role of GBP5 host genetic variation in viral immunity is novel. These findings demonstrate that rs340943904 is a strong candidate causal mutation for the SSC4 QTL that controls variation in host response to PRRSV.