Effects of Aqueous Root Extracts of Anacyclus pyrethrum on Gonadotropins and Testosterone Serum in Adult Male Rats

Abstract

In this study, we investigated effects of Anacyclus pyrethrum L. aqueous root extracts on gonadotropins (LH, FSH) and testosterone serum in adult male rats. A total number of 60 male adult rats were divided randomly into five groups (n=12) including one control group (A), sham control (B) and three test groups (C, D and E). Test groups (C, D and E) received 50, 100, 150 mg/kg does of A. pyrethrum aqueous root extracts intraperitoneally for a period of 28 days. At the end of the treatment period, the reproduction variables such as gonadotropins (LH, FSH) and serum testosterone levels were determined. The results depicted that gonadotropins and serum testosterone levels, showed a significant difference between the treatments and control groups ( P < 0.05).The results of this study showed that aqueous root extract of A. pyrethrum increased gonadotropins (LH, FSH), as well as serum testosterone levels. Experimental reports was showed that these effects may be caused due to the presence of chemical compounds in the plant. A. pyrethrum root decomposition was repeatedly shown that the extract was a resin compound called pyrethrin or pellitorin. It was reported that the alkyl amide of A. pyrethrum , pellitorin have positive effects on reproduction.