THE CLINICAL SIGNIFICANCE OF CIRCULATING PANCREATIC ANTIBODIES

Abstract

Article1 September 1960THE CLINICAL SIGNIFICANCE OF CIRCULATING PANCREATIC ANTIBODIESM. J. MURRAY, M.D., M.R.C.P., A. P. THAL, M.D.M. J. MURRAY, M.D., M.R.C.P.Search for more papers by this author, A. P. THAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-3-548 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discovery of circulating antibodies to thyroid tissue and thyroglobulin1led us to believe that iso-antibodies to pancreas might be present in chronic pancreatitis. Experimental studies, which included the production of chronic pancreatitis in animals and sensitization of animals to injected pancreatic extracts, clearly showed that antibodies to isologous pancreas were present in the sera of these animals.2We were then able to show in a preliminary study that the sera of patients with chronic pancreatic disease and carcinoma of the pancreas contained iso-antibodies specific to human pancreas.2Auto-antibodies to human pancreas have also been detected.3The present study is...Bibliography1. DoniachRoitt DIM: Auto-immunity in Hashimoto's disease and its implications, J. Clin. Endocrinol. and Metabolism 17: 1293-1304, 1957. CrossrefGoogle Scholar2. ThalMurrayEgner APMJW: Isoantibody formation in chronic pancreatic disease, Lancet 1: 1128-1129, 1959. CrossrefMedlineGoogle Scholar3. ThalEgnerMurray APWMJ: Circulating antibodies in chronic pancreatic disease, Surgical Forum 10: 240-243, 1959. Google Scholar4. Boyden SV: The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera, J. Exper. Med. 93: 107-120, 1951. CrossrefMedlineGoogle Scholar5. Ouchterlony O: Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion, Acta path. et microbiol. scandinav. 32: 231-240, 1953. CrossrefGoogle Scholar6. ThalMolestina APJE: Studies on pancreatitis, Arch. Path. 60: 212-220, 1955. Google Scholar7. BrobergerPerlman OP: Auto-antibodies in human ulcerative colitis, J. Exper. Med. 110: 657-671, 1960. CrossrefGoogle Scholar8. LapresleGrabar CP: Étude comparative de la benzidine bi-diazotée et de l'acide tannique dans les réactions d'hémagglutination obtenues avec des préparations d'insuline et des sérums diabétiques traités par l'insuline, Revue franç. étud. clin. et biol. 3: 57-59, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication April 29, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 7, 1960.From the Department of Medicine and the Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota.†This work was supported by U. S. Public Health Service Grants #H-1902 and E-1665.‡Established Investigator, American Heart Association.Requests for reprints should be addressed to M. J. Murray, M.D., Assistant Professor of Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota. 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FREDERICK FENSTER, M.D., W. WATSON BUCHANAN, M.D., LEONARD LASTER, M.D., JOSEPH J. BUNIM, M.D., F.A.C.P.The Exocrine Pancreas in Diabetes MellitusJOSEPH B. VACCA, M.D., F.A.C.P., WILBERT J. HENKE, M.D., WILLIAM A. KNIGHT JR., M.D., F.A.C.P.Human Pancreas-specific IsoantigensPancreatic Lesions in Inbred Mice Produced by Freund's AdjuvantAutoantibodies and DiseaseChronic painless pancreatitisImmunity and Hypersensitivity as Factors in the Etiology of Mesenchymal DiseasesThe PancreasSevere Hemolytic Reaction to Chlorpromazine 1 September 1960Volume 53, Issue 3Page: 548-555KeywordsAntibodiesAntigensChronic pancreatitisMedical servicesPancreasPancreatic diseasesPancreatitisSurgeryThyroidUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 September 1960 PDF downloadLoading ...