Concepedia

Tsc1 is a Critical Regulator of Macrophage Survival and Function

Chunmin Fang, Juan Yu, Yuechen Luo, Song Chen, Weiqiang Wang, Chunxiao Zhao, Zhina Sun, Wantong Wu, Wei Guo, Zhongchao Han,

Cellular Physiology and Biochemistry · 2015 · 31 citations · 15 references

DOIFull text

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Abstract

Tsc1 plays a critical role in regulating macrophage survival, function and polarization via inhibition of mTORC1 activity.

References

15

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Carey N. Lumeng, Jennifer L. Bodzin, Alan R. Saltiel · Journal of Clinical Investigation · 2007 · 4.5K citations · Full text

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

Bernard Babior, Ruby S. Kipnes, John T. Curnutte · Journal of Clinical Investigation · 1973 · 2.9K citations · Full text

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Fernando O. Martínez, Siamon Gordon, Massimo Locati et al. · The Journal of Immunology · 2006 · 2.3K citations · Full text

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Düvel, Jessica L. Yecies, Suchithra Menon et al. · Molecular Cell · 2010 · 1.9K citations · Full text

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Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

Landin Boring, J. A. Gosling, Stephen W. Chensue et al. · Journal of Clinical Investigation · 1997 · 1.1K citations · Full text

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