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HUMAN GLANDERS: REPORT OF SIX CASES

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Article1 January 1947HUMAN GLANDERS: REPORT OF SIX CASESCALDERON HOWE, WINSTON R. MILLERCALDERON HOWE, WINSTON R. MILLERAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-1-93 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGlanders, primarily an equine disease, occurs naturally in two forms, namely acute or chronic systemic glanders, and cutaneous glanders. In the past, the disease in man has usually been contracted by direct or indirect contact with infected horses. During the past 30 years, however, due to constant testing of horses and eradication of infected animals, this disease entity has been rare in this country. The only case known by the writers to have occurred in the United States in recent years was described by Herold and Erikson1in 1938. The disease occurs more frequently in Russia, the Balkans, and parts...Bibliography1. HEROLDERIKSON AACG: Human glanders—case report, South. Med. Jr., 1938, 1022. Google Scholar2. STEWART JC: Pyemic glanders in a human subject, Ann. Surg., 1904, xl, 109-113. CrossrefGoogle Scholar3. ROBINS GD: Chronic glanders in man. Studies from Royal Victoria Hospital, Montreal, 1906, Vol. ii, No. 1. Google Scholar4. BERNSTEINCABLING JMER: Observations on human glanders, Brit. Med. Jr., 1909, i, 319-325. CrossrefGoogle Scholar5. VON BRUNN A: A review of 403 cases of human glanders, Vierteljahrschr. f. Gericht. Med., 1919, lviii, 134. Google Scholar6. MCGILVRAY CD: Transmission of glanders from horse to man, Jr. Am. Vet. Med. Assoc., 1944, civ, 255-261. Google Scholar7. CROHN BB: Notes on blood cultures in human glanders, Proc. N. Y. Path. Soc., 1908, viii, 105-110. Google Scholar8. GAIGER SH: Glanders in man, Jr. Comp. Path. Ther., 1913, xxvi, 223-236. CrossrefGoogle Scholar9. SABOLOTNY SS: Diagnosis and chemotherapy in human glanders, Centralbl. f. Bakt., 1925, xcvii, 168-190. Google Scholar10. CRAVITZMILLER LWR: Immunologic studies on Malleomyces mallei and Malleomyces pseudomallei. Part I. Serology. (To be published.) Google Scholar11. MILLERPANNELL WRL: Chemotherapy of experimental glanders and melioidosis, in vitro and in vivo studies. (To be published.) Google Scholar12. HUTYRAMAREK FJ: Special pathology and therapeutics of the diseases of domestic animals, 3rd American Edition, 1926, Chicago and London. Google Scholar13. MILLERSMITHTANNER WRMGWA: Pathogenesis and pathological changes in experimental glanders and melioidosis. (To be published.) Google Scholar14. MILLERPANNELLCRAVITZTANNER WRLLWA: Studies on Malleomyces mallei and Malleomyces pseudomallei. (To be published.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Frederick, Maryland*Received for publication July 20, 1946.From the Station Hospital, Camp Detrick, Frederick, Maryland.†Isolated from the lungs of horses in 1942, and obtained from the type collection of the China Natural Epidemic Prevention Bureau.‡Strain 3873, isolated from a fatal human case in China in 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparison of three non-human primate aerosol models for glanders, caused by Burkholderia malleiLipopolysaccharides from Different Burkholderia Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient SeraOther PathogensA novel contact-independent T6SS that maintains redox homeostasis via Zn2+ and Mn2+ acquisition is conserved in the Burkholderia pseudomallei complexRapid antimicrobial susceptibility testing and β-lactam-induced cell morphology changes of Gram-negative biological threat pathogens by optical screeningUse of Immunohistochemistry to Demonstrate In Vivo Expression of the Burkholderia mallei Virulence Factor BpaB During Experimental GlandersUnderstanding about glanders among students at Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, PakistanVaccines for the Prevention of Melioidosis and GlandersAntibodies against In Vivo -Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomalleiBurkholderia pseudomallei: Challenges for the Clinical Microbiology Laboratory—a Response from the Front LineBACTERIABurkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory GlandersPhenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in MiceUse of the Common Marmoset to Study Burkholderia mallei InfectionEfficacy of Postexposure Therapy against Glanders in MiceInactivation of Burkholderia mallei in Equine Serum for Laboratory Use: TABLE 1Glanders & Melioidosis: A Zoonosis and a Sapronosis—"Same Same, but Different"Burkholderia pseudomallei and Burkholderia malleiCharacterization of cellular immune response and innate immune signaling in human and nonhuman primate primary mononuclear cells exposed to Burkholderia malleiGlanders: an overview of infection in humansParticle size and pathogenicity in the respiratory tractRevised structures for the predominant O-polysaccharides expressed by Burkholderia pseudomallei and Burkholderia malleiBurkholderia mallei and Burkholderia pseudomallei Cluster 1 Type VI Secretion System Gene Expression Is Negatively Regulated by Iron and ZincMonitoring Therapeutic Treatments against Burkholderia Infections Using Imaging TechniquesThe Respiratory SystemDistinct human antibody response to the biological warfare agent Burkholderia malleiHumoral Immune Responses in a Human Case of GlandersGlandersStructural analysis of capsular polysaccharides expressed by Burkholderia mallei and Burkholderia pseudomalleiProduction and Characterization of Chimeric Monoclonal Antibodies against Burkholderia pseudomallei and B. mallei Using the DHFR Expression SystemBurkholderia thailandensis oacA Mutants Facilitate the Expression of Burkholderia mallei -Like O PolysaccharidesEvaluation of PCR, DNA hybridization and immunomagnetic separation — PCR for detection of Burkholderia mallei in artificially inoculated environmental samplesBacterial InfectionsBurkholderia spp. and Related GeneraAntimicrobial Susceptibility of 41 Burkholderia mallei Isolates From Spontaneous Outbreaks of Equine Glanders in Punjab, PakistanBurkholderia pseudomallei and Burkholderia malleiBurkholderia mallei Cluster 1 Type VI Secretion Mutants Exhibit Growth and Actin Polymerization Defects in RAW 264.7 Murine MacrophagesBurkholderia mallei tssM Encodes a Putative Deubiquitinase That Is Secreted and Expressed inside Infected RAW 264.7 Murine MacrophagesMelioidosis and Glanders as Possible Biological WeaponsA disruption of ctpA encoding carboxy-terminal protease attenuates Burkholderia mallei and induces partial protection in CD1 miceGlandersRelationship Between Antigenicity and Pathogenicity for Burkholderia pseudomallei and Burkholderia mallei Revealed by a Large Panel of Mouse MAbsManagement of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. malleiiNOS activity is critical for the clearance of Burkholderia mallei from infected RAW 264.7 murine macrophagesDetection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected miceType VI secretion is a major virulence determinant in Burkholderia malleiThe Type IV Pilin of Burkholderia mallei Is Highly Immunogenic but Fails To Protect against Lethal Aerosol Challenge in a Murine ModelBurkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexesCritical Role of Type 1 Cytokines in Controlling Initial Infection with Burkholderia malleiDevelopment of Mouse Hybridomas for Production of Monoclonal Antibodies Specific to Burkholderia mallei and Burkholderia pseudomalleiUsing real-time PCR to specifically detect Burkholderia malleiDetection of the reemerging agent Burkholderia mallei in a recent outbreak of glanders in the United Arab Emirates by a newly developed fliP-based polymerase chain reaction assayGlanders ( Burkholderia mallei )Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in miceExperimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouseCharacterization of experimental equine glandersBacterial Agents Used for BioterrorismThe use of animal infection models to study the pathogenesis of melioidosis and glandersBurkholderia thailandensis E125 Harbors a Temperate Bacteriophage Specific for Burkholderia malleiBacterial Pathogens as Biological Weapons and Agents of BioterrorismNonviable Burkholderia mallei Induces a Mixed Th1- and Th2-Like Cytokine Response in BALB/c MiceIdentification of a Burkholderia mallei polysaccharide gene cluster by subtractive hybridization and demonstration that the encoded capsule is an essential virulence determinantLaboratory-acquired Human Glanders-Maryland, May 2000EMPYEMA AND BLOODSTREAM INFECTION CAUSED BY BURKHOLDERIA GLADIOLI IN A PATIENT WITH CYSTIC FIBROSIS AFTER LUNG TRANSPLANTATIONAtypical Pneumonia and Environmental FactorsChronic Granulomatous InfectionsZoonoses11 Occupation-related infectious arthritisRecovery of Pseudomonas gladioli from respiratory tract specimens of patients with cystic fibrosisAmerica's biological warfare program in the Second World WarMelioidosis and GlandersPathology of Glanders in Horses in IraqMelioidosis and Glanders as Possible Biological WeaponsAcute lung abscess with emphasis on medical aspectsSeltene Infektionskrankheiten, vorwiegend ZoonosenSeltene Infektionskrankheiten, vorwiegend ZoonosenViral Infections Contracted in the LaboratoryCo-existent chronic glanders and multiple cystic osseous tuberculosis treated with streptomycinStudies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomalleiThis Month in Medicine 1 January 1947Volume 26, Issue 1Page: 93-115KeywordsCyclic adenosine monophosphateInfectious diseasesLungsSystemic diseases ePublished: 1 December 2008 Issue Published: 1 January 1947 PDF downloadLoading ...

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