2015 · 13 citations · 8 references
EngineeringChemical EngineeringChromatographic AnalysisOptimizationProcess ControlAnalytical ChromatographyChromatographic SeparationChromatographyGradient-based OptimizationProcess OptimizationReal-time OptimizationChromatographic Process AnalysisConstraintsConvergenceGlobal Convergence AnalysisModel Mismatch AnalysisModel Quality AssuranceQuality MonitoringSimulation Studies
This paper is concerned with combining the use of models and of measurement to drive a plant to its optimal operation. The iterative gradient-modification optimization scheme [1] is integrated with the quadratic approximation approach [2] to enforce the global convergence and to improve the rate of convergence. The key elements of the integration, i.e. model-quality monitoring, optimization switching and empirical gradients estimation, are analyzed theoretically. Simulation studies for the optimization of chromatographic separation with considerable plant-model mismatch and process-dependent constraints are used to illustrate the potential of the proposed scheme.
8