Activation of adenosine <scp>A_2A</scp> receptor reduces osteoclast formation via <scp>PKA</scp>‐ and <scp>ERK1</scp>/2‐mediated suppression of <scp>NF</scp>κ<scp>B</scp> nuclear translocation

Abstract

A(2A)R activation inhibits OC differentiation and regulates bone turnover via PKA-dependent inhibition of NFκB nuclear translocation, suggesting a mechanism by which adenosine could target bone destruction in inflammatory diseases like rheumatoid arthritis.