The successful regression of large solid sarcoma 180 tumors by platinum compounds.

Abstract

Summary The platinum compounds, cis-platinum (IV) diamminotetrachloride, and cis-platinum (II) diamminodichloride, have been reported to be active in inhibiting and regressing small solid Sarcoma 180 tumors and Leukemia L1210 tumors in mice. They were also active in successfully regressing large (Day 8) solid Sarcoma 180 tumors in 63 to 100% of the animals, with no apparent irreversible damage to the host, in a number of dose schedules.