MYELOMATOSIS WITH XANTHOMATOSIS

Abstract

Case Reports1 January 1961MYELOMATOSIS WITH XANTHOMATOSISBOY FRAME, M.D., M. R. PACHTER, M.SC., M.D., R. K. NIXON, M.D.BOY FRAME, M.D.Search for more papers by this author, M. R. PACHTER, M.SC., M.D.Search for more papers by this author, R. K. NIXON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-1-134 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last decade considerable attention has been focused on the serum protein aberrations in multiple myeloma.1Little information has been presented, however, regarding the serum lipids and the possibility of deranged lipid metabolism in this disease. Kanzow,2in evaluating 10 patients with macroglobulinemia of Waldenström and five with myelomatosis, observed a marked decrease in serum lipids in a majority of these cases, especially in those with macroglobulinemia. Similar findings of strikingly low cholesterol values in patients with multiple myeloma were noted by Leibetseder,3Gross and Weicker,4and Lewis and Page.5Still other authors have substantiated the presence of low...Bibliography1. KorngoldLipari LR (a) : Multiple-myeloma proteins. Cancer 9: 183, 1956. (b) Petermann, M. L., Hamilton, M. G., Korngold, L.: Multiple-myeloma proteins. Ultracentrifugal and electrophoretic analysis of paucidisperse myeloma globulin. Cancer 9: 193, 1956. CrossrefMedlineGoogle Scholar2. Kanzow U: Untersuchungen über Serumlipoide bei Paraproteinamien. In European Society of Haematology, Transaction of the 6th Congress, 1957, Copenhagen, 1958, S. Karger, Basel, Part 2, p. 103. Google Scholar3. LeibetsederHugentoblerWunderlyWuhrmann FFCF: Untersuchungen über die Serumlipoide und proteine. Wien. Ztschr. inn. Med. 32: 1, 1951. MedlineGoogle Scholar4. GrossWeicker PH: Die Bedeutung des Lipoidelektrophoesediagrammes. Klin. Wchnschr. 32: 509, 1954. CrossrefMedlineGoogle Scholar5. LewisPage LAIH: Serum proteins and lipoproteins in multiple myelomatosis. Amer. J. Med. 17: 670, 1954. CrossrefMedlineGoogle Scholar6. FeiereisSehnert HHE: Seltene Form einer Paraproteinose. Klin. Wchnschr. 32: 998, 1954. CrossrefMedlineGoogle Scholar7. HillMulliganDunlop RMRMSG: Plasma cell myeloma associated with high concentrations of plasma lipoprotein. Amer. J. Path. 24: 688, 1948. MedlineGoogle Scholar8. SachsCadyRoss BAPG: Abnormal lipid-like material and carbohydrate in sera of patients with multiple myeloma. Amer. J. Med. 17: 622, 1954. CrossrefGoogle Scholar9. Waldenström J: Abnormal proteins in multiple myeloma. Advance Intern. Med. 5: 398, 1952. MedlineGoogle Scholar10. SpainGreenblattSnapperCohn DMIJIT: Degree of coronary and aortic atherosclerosis in necropsied cases of multiple myeloma. Amer. J. Med. Sci. 231: 165, 1956. CrossrefMedlineGoogle Scholar11. Lennard-Jones JE: Myelomatosis with xanthomatosis. In European Society of Haematology, Transaction of the 6th Congress, 1957, Copenhagen, 1958, S. Karger, Basel, Part 2, p. 107. Google Scholar12. Lennard-Jones JE: Personal communication, 1959. Google Scholar13. MagaliniStefaniniMarin SIMHM: Diagnostic significance of changes in free, esterified and protein-bound cholesterol, lipo- and glyco-proteins in lymphoma and multiple myeloma. Amer. J. Med. Sci. 231: 155, 1956. CrossrefMedlineGoogle Scholar14. Deuel HJ: Lipids. Vol. 2, 1955, Interscience Publishing Company, New York, p. 370. Google Scholar15. LewisPageThomas LAIHC: Effect of hepatectomy on serum lipoproteins in dogs. Amer. J. Physiol. 172: 83, 1953. CrossrefMedlineGoogle Scholar16. OssermanLawlor EFDP: Abnormal serum and urine proteins in thirty-five cases of multiple myeloma, as studied by filter paper electrophoresis. Amer. J. Med. 18: 462, 1955. CrossrefMedlineGoogle Scholar17. Hollan S, in discussion of Lennard-Jones,11 p. 108. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication June 26, 1959.From the Division of General Medicine and the Department of Pathology, Henry Ford Hospital, Detroit, Michigan.†Present address: Memorial Center for Cancer and Allied Diseases, 44 East Sixty-eighth Street, New York 21, N. Y.Requests for reprints should be addressed to Boy Frame, M.D., Henry Ford Hospital, West Grand Boulevard at Hamilton, Detroit 2, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypocomplémentémie des premières fractions de la voie classique au cours de xanthomes plans, normolipémiques, avec immunoglobulines monoclonales IgG1 (6 cas)Autoimmune hyperlipidemiaPolymeric IgA myeloma, hyperlipidaemia and xanthomatosis: a further case and reviewWALDENSTROM'S MACROGLOBULINAEMIA WITH XANTHOMATOSIS AND HYPERCHOLESTEROLAEMIAMonoclonal gammopathy with hyperlipidemiaFamilial xanthomatosis and hyperlipidemia, and myelomatosisIntroduction—a perspectiveEnergy storageRelative importance of different tissues in the synthesis of fatty acidsComparative anatomy of adipose tissue 1Adipose tissue in migratory birdsMetabolic pathways in the insect fat body 1Fat metabolism in fishThe physiological role of brown adipose tissue 1The development of adipose tissueHistogenesis 1The fine structure of adipose tissuesMorphology of adipose tissue: a microscopic anatomy of fatPathological anatomy of adipose tissue 1Lipid components of adipose tissueFatty substances containing ether linkagesFatty acid patterns in human adipose tissueStructural sugars in adipose tissueDistribution of adrenergic nerve fibers in brown and white adipose tissueStructural aspects of adipose tissue: A summary attempting to synthesize the information contained in the preceding chaptersFatty acid synthesis in adipose tissueTriglyceride metabolismEnzymes involved in carbohydrate metabolism in adipose tissueGlyceride biosynthesis, glyceride breakdown and glycogen breakdown in adipose tissue: mechanisms and regulationPathways of glucose metabolismPathways of glucose metabolism IIFructose metabolism in adipose tissue from normal and diabetic rats 1The clearing factor lipase activity of adipose tissueAdipose tissue lipases IIHormone‐sensitive lipolytic activity of adipose tissue 1Glycogen metabolism in adipose tissueAdipose tissue in diabetesRegulation of fatty acid release with particular reference to pituitary factorsRelease of free fatty acids from adipose tissue in vitro in relation to rates of triglyceride synthesis and degradationLipid peroxidation 1Net gas exchange and oxygen consumptionConversion of amino acids to fatty acidsAmino acid and protein metabolism 1Regulation of fatty acid esterification in adipose tissue incubated in vitroEffect of feeding on fatty acid synthesis 1Effects of aging on the composition and metabolism of adipose tissue in the ratEffect of biologically active peptides on adipose tissueComparative physiology of adipose tissue in different sites and in different speciesSelective labeling of adipose tissue in vivoPerfusion of isolated adipose tissue: FFA release and blood flow in rat parametrial fat bodyMetabolism of human adipose tissue in vitroThe metabolism of isolated fat cellsMetabolism of isolated adipose tissue: a summaryChylomicron metabolism: uptake and metabolism by perfused adipose tissue 1Metabolism of lipids in chylomicrons and very low‐density lipoproteinsParticulate lipid components in plasmaEffect of dietary and endocrine factors on adipose tissue growth 1The pituitary gland and the mobilization of fatThe adipokinetic property of hypophyseal peptides and catecholamines: a problem in comparative endocrinology 1In vivo and in vitro adipokinetic effects of corticotropin and related peptides 1Lipid‐mobilizing activity during fastingInhibition of lipid mobilizationAutonomic nervous system and adipose tissueAutonomic nervous system and adipose tissueAction of lipomobilizing hormones on adipose tissuePsychogenic effects on lipid mobilizationAdipositySome physiological and clinical implications of lipid mobilization from adipose tissue 1Metabolism of adipose tissue in experimental obesityThe measurement of human adipose tissue massLipid composition and metabolism of subcutaneous adipose tissue and lipoma of manLipodystrophyEffect of adipose tissue extracts on the insulin activity of human serumBibliography 1 January 1961Volume 54, Issue 1Page: 134-141KeywordsCholesterolHospital medicineHyperlipidemiaLipid metabolismLipidsMultiple myelomaMyelomaProteinsSerum proteins ePublished: 1 December 2008 Issue Published: 1 January 1961 PDF downloadLoading ...