Light microscopic observations of Morris hepatomas.

Abstract

Light microscopic examination of transplantable hepatomas with a wide spectrum of growth rates and analysis of structure based on the criteria of Elias reveal rough correlations between structure and growth rate. Fast-growing hepatomas are formed by multicellular laminae, have small cells and abundant mitoses, and lack glycogen and follicles. Hepatomas with intermediate growth rates contain tubular and follicular structures. Slowly growing hepatomas contain single-cell laminae. However exceptions are many, particularly among the slowly growing hepatomas.