Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)‐1 stabilizes K_v1.5 channels in HL‐1 cells

Abstract

HSF-1 induced transcription of SAP97 through SIRT1-dependent interaction with HSEs; the increase in SAP97 resulted in stabilization of K(v)1.5 channels. These effects were mimicked by GGA.