Journal of neurosurgery · 1985 · 600 citations · 26 references
MedicineNeurologyNeuroscienceClinical NeuroscienceNeurodegenerationTransplant SurgeryBasal GangliaCell EngraftmentNervous TissueParkinson DiseaseParkinson Disease SurgeryParkinsonian DisordersAdrenal Medulla HormonesNeural Cell EngraftmentStriatal FunctionStriatal Physiology
The study aimed to supply the striatum with a new catecholamine source via adrenal medullary tissue transplantation. The authors transplanted autologous adrenal medullary tissue into the striatum of two severe parkinsonism patients. The procedure produced some rewarding effects, marking the first human brain transplantation of adrenal medullary tissue and suggesting the need for further trials.
Autologous adrenal medullary tissue was transplanted to the striatum in two patients with severe parkinsonism. The aim was to provide the striatum with a new cellular source of catecholamines. Some rewarding effects were registered. This is the first time that such tissue has been transplanted in the human brain. The results merit further clinical trials.
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Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System
Mark J. Perlow, William J. Freed, Barry J. Hoffer et al. · Science · 1979 · 964 citations
Medicine, Neurobiology, Neuroscience +17