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Unusual phenotypes of human inducer T cells as measured by OKT4 and related monoclonal antibodies.
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1981
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Unusual PhenotypesLaboratory ImmunologyLymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunologyPathologyCd4 T Cell ResponsesImmune SystemImmunotherapyInducer/helper T CellsNew Monoclonal AntibodiesMurine Monoclonal AntibodyAllergyAutoimmune DiseaseAutoimmunityT Cell ImmunityT Cell BiologyCellular Immune ResponseMonoclonal AntibodiesMedicine
OKT4, a murine monoclonal antibody, was previously shown to react with inducer/helper T cells in man. We now report the absence of this reactivity in 2 subjects of African ancestry and the production of 4 new monoclonal antibodies (OKT4A-D) that detect distinct antigens on human inducer/helper T cells.