Neuropathology and <scp>C</scp>ellular <scp>P</scp>athogenesis of <scp>S</scp>pinocerebellar <scp>A</scp>taxia <scp>T</scp>ype 12

Abstract

SCA12 involves extensive, but selective, neurodegeneration distinct from Alzheimer's disease, synucleinopathies, tauopathies, and glutamine expansion diseases. SCA12 neuropathology may arise from the neurotoxic effect of repeat-expansion-induced overexpression of PPP2R2B.