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The importance of implantation site in cerebral carcinogenesis in rats.
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1969
Year
PathologyGliomaTumor BiologySocial SciencesNeuro-oncologyEndocrine OncologyNeuroregenerationImplantation (Embryology)Cancer Cell BiologyDeeply Implanted PelletsRadiation OncologyDeep PositionCancer ResearchMalignant DiseaseTumoral PathologyDevelopmental BiologyNeuroanatomyBrain Tumor BiologyNeuroscienceMedicineSummary PelletsImplantation Site
Summary Pellets of the chemical carcinogens 3,4-benzpyrene and 20-methylcholanthrene were implanted into the brains of 20 male and 20 female rats. The position of the carcinogen within the brain was carefully controlled in order to involve either the lateral ventricles (“deep”) or the meninges (“superficial”). A preponderance of tumors developed where the carcinogen was situated in the deep position (77%) compared with only 11% of the tumors from superficially situated pellets. Tumors from the deeply implanted pellets, of which all but one were gliomas, were more common and tended to develop earlier in males than in females. It was suggested that involvement of the subependymal plate accounted for this high incidence of tumors, and comparisons were made between our results and the incidence of glial tumors in man.