Polymorphisms in the +252(A/G) lymphotoxin‐alpha and the −308(A/G) tumor necrosis factor‐alpha genes and susceptibility to chronic periodontitis in a Czech population

Abstract

Our data suggest that combined genotypes composed of the TNF-alpha and LT-alpha gene polymorphisms may influence the susceptibility to chronic periodontitis. We also showed that, comparing the two genes, the 1/1 genotype of the NcoI polymorphism in the first intron of the LT-alpha gene is a more informative marker and it may be one of the protective genetic factors against chronic periodontitis in our population.