9,10‐Dihydro‐2,5‐dimethoxyphenanthrene‐1,7‐diol, from <i>Eulophia ochreata</i>, inhibits inflammatory signalling mediated by Toll‐like receptors

Abstract

RSCL-0520 blocked signals generated by TLR4 activation, as shown by down-regulation of NF-kappaB-regulated inflammatory cytokines. The inhibitory effect involved both MyD88-dependent and -independent signalling cascades. Our data elucidated the molecular mechanisms involved, and support the search for plant-derived TLR antagonists, as potential anti inflammatory agents.