Chemical and Cytotoxicity Survey on the Production of Ochratoxins and Penicillic Acid by Aspergillus ochraceus WILHELM

Abstract

Thirty-three strains of Aspergillus ochraceus isolated from foods in Japan were examined for the bioproduction of toxic metabolites, and the formation of ochratoxins by two strains and of penicillic acid by twenty-eight strains was proved. The two toxins and other metabolites were isolated and identified. Toxicities shown by the metabolites were examined by HeLa cells and the relation with some metabolites was discussed from the similarities of morphological pattern by a group of strains.