The electromechanical window is no better than <scp>QT</scp> prolongation to assess risk of <scp>T</scp>orsade de <scp>P</scp>ointes in the complete atrioventricular block model in dogs

Abstract

In the canine CAVB model, ventricular remodelling and I(Kr) block by dofetilide are associated with negative EMW values, but this reflects QT prolongation, and implies that the EMW lacks specificity to predict dofetilide-induced TdP.