MODIFICATION OF ABNORMAL SERUM LIPID PATTERNS IN ATHEROSCLEROSIS BY ADMINISTRATION OF SITOSTEROL

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Article1 October 1956MODIFICATION OF ABNORMAL SERUM LIPID PATTERNS IN ATHEROSCLEROSIS BY ADMINISTRATION OF SITOSTEROLMAURICE M. BEST, M.D., F.A.C.P., CHARLES H. DUNCAN, M.D.MAURICE M. BEST, M.D., F.A.C.P., CHARLES H. DUNCAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-4-614 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe reports by Peterson that the addition of soybean sterols to experimental diets of chicks appeared to inhibit the absorption of cholesterol1 and to effect a decreased incidence of atherosclerosis2 have stimulated study of the effects of ingestion of various plant sterols.The presence in higher plants of sterols (phytosterols) which are closely related to cholesterol has long been recognized. The most widely distributed of the phytosterols are the sitosterols, of which there are at least five. Gamma sitosterol is the principal sterol of soybean oil, and presumably the active component of the sterol mixture employed by Peterson. Studies in...Bibliography1. Peterson DW: Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks, Proc. Soc. Exper. Biol. and Med. 78: 143, 1951. CrossrefMedlineGoogle Scholar2. PetersonNicholsShneour DWCWEA: Some relationships among dietary sterols, plasma and liver cholesterol levels and atherosclerosis in chicks, J. Nutrition 47: 57, 1952. CrossrefMedlineGoogle Scholar3. PageBrown IHHB: Induced hypercholesterolemia and atherogenesis, Circulation 6: 681, 1952. CrossrefMedlineGoogle Scholar4. Pollak OJ: Successful prevention of experimental hypercholesteremia and cholesterol atherosclerosis in the rabbit, Circulation 7: 696, 1953. CrossrefMedlineGoogle Scholar5. BestDuncanVanloonWathen MMCHEJJD: Lowering of serum cholesterol by the administration of a plant sterol, Circulation 10: 201, 1954. CrossrefMedlineGoogle Scholar6. BestDuncanVanloonWathen MMCHEJJD: Effects of sitosterol on serum lipids, Am. J. Med. 19: 61, 1955. CrossrefMedlineGoogle Scholar7. BestDuncan MMCH: The effects of sitosterol on the concentration of serum and liver cholesterol in hypothyroidism, Circulation, in press. Google Scholar8. HernandezPetersonChaikoffDauben HHDWILWG: Absorption of cholesterol-4-C14 in rats fed mixed soybean sterols and beta sitosterol, Proc. Soc. Exper. Biol. and Med. 83: 498, 1953. CrossrefMedlineGoogle Scholar9. Davis WW: The physical chemistry of cholesterol and beta sitosterol related to the intestinal absorption of cholesterol, Tr. New York Acad. Sc. 18: 123, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Kentucky*Presented at the Thirty-seventh Annual Session of The American College of Physicians, Los Angeles, California, April 17, 1956.From the Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.†With the technical assistance of JOAN D. WATHEN, B.S., and URSULA JEGHER.This investigation was supported by research grants from Eli Lilly & Co., Indianapolis, Indiana, and the Commonwealth of Kentucky Medical Research Commission.Requests for reprints should be addressed to Maurice M. Best, M.D., Louisville General Hospital, 323 East Chestnut Street, Louisville, Kentucky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemiaTLC Detection of β-sitosterol in Michelia champaca L. 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Coronarinsuffizienz, Angina pectoris und HerzinfarktThe effect of sitosterol on radioactive fat absorption patternsSymposium on Cerebrovascular Disease—Part IICholesterol and Its Relation to AtherosclerosisSitosterol FeedingThe effects of corn oil on serum lipids in normal active subjects 1 October 1956Volume 45, Issue 4Page: 614-622KeywordsAtherosclerosisCholesterolDietIngestionLipidsOilsResearch grantsSterols Issue Published: 1 October 1956 PDF downloadLoading ...