PRIMARY AND SECONDARY MYELOFIBROSIS (A CLINICAL AND PATHOLOGICAL STUDY OF THIRTEEN CASES OF FIBROSIS OF THE BONE MARROW)

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Article1 November 1944PRIMARY AND SECONDARY MYELOFIBROSIS (A CLINICAL AND PATHOLOGICAL STUDY OF THIRTEEN CASES OF FIBROSIS OF THE BONE MARROW)LOWELL A. ERF, M.D., F.A.C.P., PETER A. HERBUT, M.D.LOWELL A. ERF, M.D., F.A.C.P.Search for more papers by this author, PETER A. HERBUT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-5-863 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMyelofibrosis means fibrosis of the bone marrow. The process may be either focal or generalized, primary or secondary, mild or severe, and may or may not be associated with various degrees of myelosclerosis (defined as an excessive proliferation of endosteal bone, known also as osteosclerosis) in any or all bones of the body. Among others, fibrosis of the bone marrow has been observed in the following conditions:A. Focal:I. Primary (idiopathic),1. 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