Monitoring for multidrug‐resistant <i>Plasmodium falciparum</i> isolates and analysis of pyrimethamine resistance evolution in Uige province, Angola

Abstract

The parasite population of Uige Angola has high frequency mutations in pfcrt, dhfr and dhps associated with resistance to chloroquine and sulphadoxine pyrimethamine, reflecting past reliance on these two drugs which were the mainstay of treatment until recently. Our findings show that drug resistance in Uige has occurred through a combination of local drug pressure and the regional and international dispersal of resistance mutant alleles.