The ω3‐polyunsaturated fatty acid derivatives <scp>AVX</scp>001 and <scp>AVX</scp>002 directly inhibit cytosolic phospholipase <scp>A</scp>₂ and suppress <scp>PGE</scp>₂ formation in mesangial cells

Abstract

These data show for the first time that the novel cPLA(2) inhibitors AVX001 and AVX002 exert an anti-inflammatory effect in cultures of renal mesangial cells and reduce the pro-inflammatory mediator PGE(2) through an inhibitory effect on NF-κB activation. Therefore, these compounds may represent promising novel drugs for the treatment of inflammatory disorders.