Stability of Midazolam Prepared for Oral Administration

Abstract

Midazolam is used frequently as an oral premedication in children. To make it more palatable, it is often mixed in various syrups and solutions. No previous studies have documented the stability of midazolam when mixed in these solutions. Using high-pressure liquid chromatography, we assayed midazolam concentrations over time when mixed at two different concentrations (2.5 mg/mL and 3.0 mg/mL) in a sucrose-based syrup (Simple Syrup, NF). Each assay was done in triplicate on three different days (days 1, 14, and 38). Solution A concentrations (2.5 mg/mL) were 2.28 mg/mL on day 1, mg/mL) were 2.82 mg/mL on day 1, 2.91 mg/mL on day 14, and 2.24 mg/mL on day 38. Our results confirm the stability of midazolam for up to 14 days when mixed for oral administration.