In vivo human-hamster somatic cell fusion indicated by glucose 6-phosphate dehydrogenase and lactate dehydrogenase profiles.

Abstract

Transplantation of a human lymphoma to the cheek pouches of unconditioned, adult golden hamsters resulted in permanently transplantable tumors which grow progressively and kill their hosts. This tumor system, GW-478, has a hamster-specific lactate dehydrogenase isoenzyme mobility pattern and both human and hamster glucose 6-phosphate dehydrogenase enzyme profiles when propagated in the hamster or in vitro , thus suggesting that GW-478 is a human-hamster hybrid.