Lesch‐Nyhan syndrome‐like behavior in rats from caffeine ingestion

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

Adenosine 3‘,5‘-Phosphate in Biological Materials

R.W. Butcher, Earl W. Sutherland · Journal of Biological Chemistry · 1962 · 2.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

The Metabolic Basis of Inherited Disease

Lawrence M. Solomon · Journal of Investigative Dermatology · 1979 · 2.1K citations

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A familial disorder of uric acid metabolism and central nervous system function

Michael Lesch, William L. Nyhan · The American Journal of Medicine · 1964 · 1.5K citations

Life Sciences, Neurology, Neuroscience +9

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

J. Edwin Seegmiller, Frederick M. Rosenbloom, William N. Kelley · Science · 1967 · 1.2K citations

Life Sciences, Biochemistry, Neurology +14