Synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of <i>Annona muricata</i> and <i>Piper nigrum</i> against the dengue fever vector <i>Aedes aegypti</i>

Abstract

It is suggested that the different mechanisms of action of the larvicidal actives A. muricata acetogenins and P. nigrum piperamides explain the observed synergism. The combination of inexpensive botanicals and a low-cost organosolvent such as ethanol leads to a simple and efficient phytolarvicidal formulation.