Frontiers in Computational Neuroscience · 2013 · 26 citations · 204 references
Life SciencesBiophysicsNeuroscienceElectrophysiologyNeurobiophysicsNeurophysiologyBiophysical Neuron ModelingNeural Circuit DynamicsNeural Recording TechnologiesNeural Signal AcquisitionNeural Signal ProcessingNeuronal DynamicsEnergy DissipationHigh-density Neural RecordingMagnetic ResonanceMultichannel Neural RecordingNeural RecordingNeural Recording SystemsOptical Neural RecordingSpatial Resolution In Neural Recording
Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. We outline the physical principles governing brain activity mapping using optical, electrical, magnetic resonance, and molecular modalities of neural recording. We analyze the scalability of each method in the mouse brain, focusing on limits from spatiotemporal resolution, energy dissipation, and volume displacement, and study the physics of powering and communicating with microscale devices embedded in brain tissue. Entirely new approaches may be required, motivating an analysis of the fundamental physical constraints on the problem.
Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, motivating an analysis of the fundamental physical constraints on the problem. We outline the physical principles governing brain activity mapping using optical, electrical,magnetic resonance, and molecular modalities of neural recording. Focusing on the mouse brain, we analyze the scalability of each method, concentrating on the limitations imposed by spatiotemporal resolution, energy dissipation, and volume displacement. We also study the physics of powering and communicating with microscale devices embedded in brain tissue.
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