Neurology · 1992 · 33 citations · 0 references
MedicineNeurologyPathologyDementiaGlial BiologyNeuropathologyBrain TumorsCentral Nervous System TumorsGlial PathologyMicroglia BiologyNervous TissueNeurodegenerative DiseasesAmyloid Plaque FormationAmyloid PlaquesAmyloidogenic PeptidesAmyloidogenic ProteinsBrain Tumor PathologyWhite Matter LesionsWhite Matter MicrostructureWhite Matter Pathology
We report a 32-year-old man with a 4-year history of headaches, seizures, and dementia secondary to multifocal amyloidomas in the white matter. Immunohistochemical and electron microscopic analyses suggest that the amyloidomas resulted from processing of plasma-cell-derived amyloidogenic protein by microglial cells.