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The Incorporation of 6-Mercaptopurine-S35 into the Nucleic Acids of Sensitive and Nonsensitive Transplantable Mouse Tumors
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1961
Year
PathologyMercaptopurine-resistant SublineCancer BiologyTumor BiologyAdenocarcinoma 755Radiopharmaceutical TherapyAnti-cancer AgentSensitive LineCell TransplantationRadiation OncologyCancer ResearchXenotransplantationMedicineTumor TargetingCancer TreatmentPharmacologyMalignant DiseaseCell BiologyOncologyNucleic Acids
Summary The incorporation of 6-mercaptopurine-S35 into the deoxyribonucleic acids of several mouse tumors has been studied, with the use of standard chemotherapeutic regimens. No correlation could be found between the concentration of 6-mercaptopurine incorporated and the degree of inhibition of the tumor. Furthermore, a mercaptopurine-resistant subline of Adenocarcinoma 755 incorporated more of the analog than did the sensitive line.