Publication | Closed Access
Different Localization of Tau Protein Kinase I/Glycogen Synthase Kinase-3β from Glycogen Synthase Kinase-3α in Cerebellum Mitochondria
57
Citations
0
References
1995
Year
MitophagySubcellular FractionationGlycogen Synthase Kinase-3αMolecular BiologyMitochondrial BiologyTau ProteinCellular PhysiologyMitochondrial BiogenesisCerebellum MitochondriaMitochondrial StructureCell SignalingDifferent LocalizationMolecular NeuroscienceMolecular PhysiologyMitochondrial DynamicCell BiologySignal TransductionMitochondrial FunctionNatural SciencesPhysiologyMitochondrial BioenergeticsCellular BiochemistryMedicineGlycogen Synthase Kinase-3
We examined the subcellular distribution of two glycogen synthase kinase-3 (GSK-3) isoforms in rat cerebellum. Results from immunoelectron microscopy and subcellular fractionation revealed that one isoform, tau protein kinase I/GSK-3 beta (TPKI/GSK-3 beta), was present in mitochondria, but GSK-3 alpha was not. Although the two GSK-3 isoforms seem to have similar properties, the difference of subcellular localization observed here suggests that TPKI/GSK-3 beta fulfills some specific function in mitochondria.