Persistent formation of reagins in mice injected with low doses of ovalbuminl.

Abstract

Immunization of mice with minute doses (0.1 μg) of ovalbumin in A1(OH)(3) gel induced persistent synthesis of high titres (1:160, 1:320) of reaginic and IgG1 antibodies. Immunization with high doses of ovalbumin (100 μg) induced high IgG1 titres but only weak and transient formation of reagins. Inbred mouse strains differ widely in their immune responsiveness to low doses of ovalbumin.