Concepedia

Inhibition of prolipoprotein signal peptidase by globomycin.

I K Dev, Richard J. Harvey, Paul H. Ray

Journal of Biological Chemistry · 1985 · 122 citations · 17 references

DOIFull text

Open access

Concepts

Abstract

Globomycin inhibits the prolipoprotein-specific signal peptidase activity by binding to the enzyme in a noncompetitive manner (Ki = 36 nM). The Km of prolipoprotein signal peptidase for the prolipoprotein substrate is 6 (+/- 1) microM.

References

17

Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane

Grant Fairbanks, Theodore L. Steck, Donald F. H. Wallach · Biochemistry · 1971 · 8.6K citations

, , +9

Statistical estimations in enzyme kinetics

GN WILKINSON · Biochemical Journal · 1961 · 3.6K citations · Full text

, , +15

Allosteric proteins and cellular control systems

Jacques Monod, Jean‐Pierre Changeux, François Jacob · Journal of Molecular Biology · 1963 · 2.2K citations

, , +13

Amino acid sequence for the peptide extension on the prolipoprotein of the Escherichia coli outer membrane.

S Inouye, Sen Wang, Jun Sekizawa et al. · Proceedings of the National Academy of Sciences · 1977 · 290 citations · Full text

, , +11

Accumulation of glyceride-containing precursor of the outer membrane lipoprotein in the cytoplasmic membrane of Escherichia coli treated with globomycin.

Musaddeq Hussain, Shigeyuki Ichihara, San-ichiro Mizushima · Journal of Biological Chemistry · 1980 · 268 citations · Full text

, , +11