The Effect of Neoplasia on the Turnover of Nucleic Acids Studied with Formate-C14 and Glycine-2-C14

Abstract

Summary The incorporation of formate-C 14 and glycine-2-C 14 into DNA of liver, spleen, intestine, and tumor tissue and into cPNA of liver was measured, 4 hours after the administration of the precursor, in male A strain mice bearing transplants of mammary carcinoma or sarcoma A274. An increase in the specific activity was observed in the liver and spleen DNA of tumor-bearing mice as compared to the DNA of the same tissues from control mice. The specific activity of the DNA of the intestine was lower in all the tumor-bearing mice than the controls. The liver cPNA specific activity was essentially the same in the mice with tumor transplants as in the control mice.