Increased levels of tumour necrosis factor alpha (<scp>TNF</scp>α) but not transforming growth factor‐beta 1 (<scp>TGF</scp>β1) are associated with the severity of congenital hydrocephalus in the hyh mouse

Abstract

In the hyh mouse model of congenital hydrocephalus, TNFα and TNFαR1 appear to be associated with the severity of the disease, probably mediating the astrocyte reaction, neurodegenerative processes and ischaemia.