Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells☆☆Supported by Grant S1-200000440 from Fondo Nacional de Ciencia, Innovación y Tecnologia (FONACIT), Ministerio de Ciencia y Tecnologia.

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DOI

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2003

Year

Samandhy Cedeño, Domenico F Cifarelli, Ana M. Blasini, M. Boquete Paris, Fabiola Pláceres, Guillermina Alonso, Martín A. Rodríguez

Clinical Immunology

Signal TransductionAutoimmune DiseaseSystemic Lupus ErythematosusSystemic Lupus Erythematosus TreatmentLupusProtein Grb2Signaling PathwayImmunologyCell RegulationLupus TLupus NephritisAutoimmunityMedicineCell BiologyCell SignalingCell Development