The age of the tumor-bearing hosts as a factor conditioning the transmissibility of the Rous sarcoma by filtrates and cells.

Abstract

Summary The filtrability of the Rous sarcoma is inversely related to the age of the hosts and age of the tumors. Also, the tumors induced by cell suspensions have a higher filtrability than those induced by filtrates. The transmissibility of the tumors by cells is inversely related to the age of tumors and, under certain conditions, directly related to their filtrability. The occurrence of metastases is directly related to the filtrability of the tumors and to their transmissibility by cells. Virus can be recovered from the nonfiltrable tumors by passage of the sarcoma cells into other hosts. The findings are discussed in relation to the effect of the age factor on the tumor and its causative virus.