H‐Chain Ferritin: A Natural Nuclei Targeting and Bioactive Delivery Nanovector

Abstract

Nuclear translocation of human H-chain in its intact cage-like structure without any additional modifications enables a rapid nuclear delivery of an encapsulated anticancer drug (doxorubicin). This reduces the doses of drugs simultaneously bypassing the cellular multidrug resistance. Apoferritin exhibits synergistic effects through attenuating drug-induced dysregulation of the cellular iron. Tests on cerebellar organotypic cultures show the natural cell selectivity and drug accumulation in brain tissue. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.