The Journal of Immunology · 1988 · 152 citations · 0 references
Life SciencesImmunologyInfectious DiseasesCellular ImmunologyImmunoregulationMolecular ImmunologyAntiretroviral TherapyAntiviral ImmunityImmunodeficiency DisordersT Cell ActivationT Cell BiologyAntiviral T Cell ResponsesCd4 Positive T Cell ResponsesCd4 Positive T CellsCd4 T Cell ActivationCd4+ T Helper Cell ResponsesHiv-associated ImmunosuppressionMurine Hybridoma SystemsT-cell Immune Responses
The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing to the immunosuppression observed after HIV infection. Using a murine T cell hybridoma which expresses the human CD4 protein and exhibits a CD4-dependent response to Ag, we demonstrate that the HIV envelope protein gp120 can specifically inhibit this response.