Effect of Bramhi Ghrita, an polyherbal formulation on learning and memory paradigms in experimental animals

Abstract

OBJECTIVE: To investigate the neuropsychopharmacological effect of a polyherbal formulation Bramhi Ghrita (BG) on learning and memory processes in rats by elevated plus maze, and in mice by Morris water maze model. MATERIAL AND METHODS: BG contains Bacopa monneri (Bramhi), Evolvulus alsinoids, Acorus calamus, Saussurea lappa and cow's ghee. Its effect (30, 50 and 100 mg/kg, p.o.) was tested on learning and memory processes. The activity of BG on memory acquisition and retention was studied using elevated plus maze model (EPM) in rats, and on spatial memory using Morris water maze model (MWM) in mice. The alcoholic extract of Bacopa monneri (40 mg/kg, p.o.) was also administered to one group of animals. The results were compared with the vehicle-treated group. RESULTS: Administration of Bramhi Ghrita (50 and 100 mg/kg, p.o.) showed significant reduction in transfer latency in EPM and escape latency in MWM as compared with the control group. CONCLUSION: BG may act as a memory enhancer formulation and may also be useful as a supportive adjuvant in the treatment of impaired memory functions.