Protective effect against ischemia and light damage of iris pigment epithelial cells transfected with the BDNF gene.

Abstract

BDNF-transfected IPE cells demonstrated a neuronal rescue effect in both in vitro and in vivo experiments. IPE cells may be a potential source for autologous cell transplantation for some retinal diseases, and the transfection of the genes of neurotrophic factors into the transplanted cell may be a useful tool for delivering these factors to the retina.